Preliminary study on manufacture process of transdermal patch of nitroglycerin

ABSTRACT

Nitroglycerin, a vasoactive substance, has been used in the treatment of vagina for more than 100 years. To sustain the pharmaceutical effect, doses were administered every 2 hours. Recently the transdermal delivery systems have became popular. Based on eudragit E 100, we combined it with plasticizer (dibutyl sebacate/triethyl citrate), crosslinker (succinic acid), active ingredient (nitroglycerin) and further excipients (e.g. permation enhances ethyl alcohol) to form a self adhesive matrix system for use in nitroglycerin patch. The concentration of nitroglycerin in the patch was determined by HPLC assay