Extended adjuvant temozolomide for treatment of glioblastoma multiforme:experience of a single institu- tion / 实用医学杂志
The Journal of Practical Medicine
; (24): 2743-2746, 2017.
Article
em Zh
| WPRIM
| ID: wpr-611800
Biblioteca responsável:
WPRO
ABSTRACT
Objective To assess the impact of additional cycles of temozolomide on the survival of glio-blastoma(GBM)patients after 6 months of maintenance temozolomide(TMZ)following concurrent TMZ chemo-therapy and radiation therapy. Methods Data of 51 GBM patients from 2009 to 2015 were retrospectively studied and the therapeutic effect was assessed according to whether receiving long-term treatment with TMZ. Results Sev-enteen of fifty-one GBM patients received 8 or more cycles and prolonged treatment improved progression-free sur-vival(P=0.011)and overall survival(P=0.004). Conclusions Extended use of TMZ is safe to GBM patients , which may improve response OS and PFS compared to conventional regimen. Prospective studies in larger popula-tions are needed to better-define the population to whom it can be proposed and its optimal duration.
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Índice:
WPRIM
Tipo de estudo:
Observational_studies
Idioma:
Zh
Revista:
The Journal of Practical Medicine
Ano de publicação:
2017
Tipo de documento:
Article