Preparation and Formulation Optimization of Nanostructured Lipid Carriers of Adefovir Dipivoxil / 中国药房
China Pharmacy
;
(12): 2259-2261, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-612502
ABSTRACT
OBJECTIVE:
To prepare nanostructured lipid carrier of adefovir dipivoxil(ADV-NLC),and optimize the formula-tion.METHODS:
Using stearic acid and glycerin monostearate as solid lipid,oleic acid as liquid lipid,Gemini surfactant and poly-sorbate 80 as emulsifier,sodium dodecyl sulfate (SDS) as stabilizer,solvent dispersion ultrasonic method was used to prepare ADV-NLC. And using particle size,polydispersity index,Zeta potential,encapsulation efficiency as indexes,single factor test was conducted to screen Gemini surfactant-polysorbate 80 ratio,emulsifier dosage(ratio of emulsifier to water phase),drug-lipid ratio, solid-liquid lipid ratio.RESULTS:
The formula was as follow as 3% emulsifier (Gemini surfactant-polysorbate 80 ratio of 12), 4.5% drug-lipid ratio,solid-liquid lipid ratio of 65. The average particle size of the prepared ADV-NLC was(48.83±2.65)nm, polydispersity index<0.3,Zeta potential was(-28.7±1.8)mV,encapsulation efficiency was(77.65±0.03)%(n=3). CONCLU-SIONSADV-NLC is successfully prepared,and the formulation is reasonable and feasible.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2017
Tipo de documento:
Artigo
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