Observation of effects of amino acid combined with Salvia miltiorrhiza injection on fetal growth restriction / 中国基层医药

ABSTRACT

Objective To investigate the effects of amino acid combined with Salvia miltiorrhiza injection on fetal growth restriction.Methods 122 pregnant women diagnosed with fetal growth restriction were chosen,and they were divided into study group(amino acid+Salvia miltiorrhiza injection) and control group(amino acid).The course of treatment was 7d,and the patients were treated for 3 treatment courses.The clinical efficacy,weight increment,uterine height increment,abdominal circumference increment,fetal biparietal diameter (BPD) increment,femur length (FL) increment,umbilical cord blood flow S/D value and neonatal weight between the two groups were compared.Results The total effective rate in the study group was 84.13%,which was higher than 67.79% in the control group (χ2=4.484,P<0.05).In the study group,the body weight gain,the uterine height increment,abdominal circumference increment were (523.21±103.72)g,(2.88±0.52)cm and (3.19±0.75)cm,respectively,which were significantly higher than those in the control group(t=2.215,4.402,2.328,all P<0.05).The uterine height increment and abdominal circumference increment in the intermediate stage of the study group were (2.14±0.27)cm and (2.89±0.52)cm,respectively,which were significantly higher than those of the control group,and the differences were significant(t=1.503,2.097,all P<0.05).In the study group,the BPD increment and FL increment at prophase and intermediate stage were (2.69±1.23)mm and (2.24±0.97)mm,(2.61±1.28)mm and (2.19±1.28)mm,respectively,which were significantly higher than those in the control group (t=2.053 and 2.244,2.038 and 2.128,all P<0.05).The S/D values of umbilical cord blood flow in early stage,middle stage and anaphase of the study group were (2.33±0.19),(2.46±0.17) and (2.12±0.14),which were significantly lower than those of the control group (t=4.040,2.9817 and 4.418,all P<0.05),the differences were statistically significant.The neonatal weight of the study group was (2 576.18±621.04)g,which of the control group was (2 384.09±428.76)g,and there was significant difference between the two groups(t=1.999,P<0.05).Conclusion Amino acid combined with Salvia miltiorrhiza injection can effectively improve the clinical indicators of pregnant woman and fetal growth restriction,with good clinical effects.