Pathogenesis of insulin resistance and its impact on antiviral therapy in patients with chronic hepatitis C / 临床肝胆病杂志

ABSTRACT

Chronic hepatitis C virus (HCV) infection is an important cause of hepatic fibrosis,liver cirrhosis,and hepatocellular carcinoma (HCC).Insulin resistance (IR) is one of the important pathological features of HCV infection.IR can accelerate the development of hepatic fibrosis,hepatic steatosis,and HCC and affect the efficacy of antiviral therapy.Therefore,HCV-related IR can be the target of pharmacotherapy during any stage of HCV infection.This article reviews the pathogenesis of IR in patients with hepatitis C,the interaction between them,and the impact of IR on antiviral therapy.