Analysis of clinical efficacy of amlodipine combined with telmisartan capsules in the treatment of hypertension / 中国生化药物杂志

ABSTRACT

Objective To investigate the clinical effect of amlodipine combined with Telmisartan Capsules in the treatment of hypertension.MethodsThe patients with primary hypertension in 87 cases in the second hospital affiliated to Tianjin Medical University were divided into two groups.43 patients in control group were treated with amlodipine 2.5~5mg/d orally, 44 patients in the experimental group on the basis of combined with Telmisartan Capsules 40~80mg/d orally, the total course of treatment was eight weeks.The changes of blood pressure levels were compared before and after treatment, the effective rate of the treatment and adverse reactions after treatment, to evaluate the clinical efficacy of amlodipine combined with Telmisartan Capsules in the treatment of hypertension.ResultsAfter treatment, two groups of three blood pressure index were significantly decreased (P<0.05), compared with the control group, the experimental group of patients with treatment After treatment the blood pressure level is low(P<0.05).After eight weeks of treatment, the total efficiency of control group was 72.09%, the total efficiency of experimental group was 95.45%, the experimental group was higher than that in the control group (P<0.05) after treatment, patients in the control group with two cases of headache (4.65%), two cases of lower extremity edema (4.65%);the experimental group of two cases of vertigo (4.55%), three cases of joint pain (6.82%), there was no significant difference in total adverse reaction rate between the two groups.Conclusion Amlodipine combined with Telmisartan Capsules in the treatment of hypertension has good clinical effect.