Expressions and Clinical Significances of AEG-1 and MMP-9 in the Oral Squamous Cell Carcinoma / 现代生物医学进展

ABSTRACT

Objective:To study the expressions and clinical significances of astrocyte elevated gene-1 (AEG-1) and matrix metal loproteinase-9 (MMP-9) in the oral squamous cell carcinoma (OSCC).Methods:The expressions of AEG-1 and MMP-9 were detected by immunohistochemistry method in 53 cases of OSCC patients and 30 cases of controls with normal oral mucosa tissues.The relation ship of AEG-1 and MMP-9 expressions with the clinicopathologic features were analyzed.Results:The postive expressions of AEG-1 and MMP-9 in the OSCC(66.03 ％,73.58 ％) were signifiacnatly higher than those of the normal oral mucosa tissue (13.33 ％,16.67 ％) (P＜0.01).The expression of AEG-1 was positively correlated with with the expression of MMP-9 (r=0.474,P＜0.01).The high expressions of AEG-1 and MMP-9 were associated with the differentiation degree,lymph node metastasis and clinical stage,but they were not correlated with the gender,age and smoker.Conclusions:The high expression of AEG-1 and MMP-9 were closely related to the occurrence,development and metastasis of OSCC.Therefore,combined detection of AEG-1 and MMP-9 might be valuable for the early diagnosis and prognostic prediction of OSCC.