Interleukin-27 Enhances TNF-α-mediated Upregulation of Inflammatory Cytokine and Chemokine / 现代生物医学进展
Progress in Modern Biomedicine
;
(24): 4412-4415, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-615074
ABSTRACT
Objective:
Immune cells and inflammatory mediators play important roles in the development of atherosclerotic vascular inflammation.This study focuses on the direct effect ofIL-27 on human coronary artery endothelial cells.Methods:
In this study,the effects of IL-27 and TNF-α on inflammatory cytokines and chemokines were investigated.Results:
IL-27 could significantly enhance the TNF-α-mediated upregulation of inflammatory cytokine IL-6 and chemokines CCL5 from human coronary artery endothelial cells.The release of IL-6 and CCL5 was significantly suppressed by specific signaling molecule inhibitors.Conclusion:
The induction of these mediators from the human coronary artery endothelial cells could be differentially regulated by the c-Jun N-terminal kinase,p38 mitogen-activated protein kinase,and nuclear factor-κB pathways.These results provided new insights into the effect of IL-27 on the TNF-α mediated activation of human coronary artery endothelial cells in atherosclerotic vascular inflammation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Progress in Modern Biomedicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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