Effect of Post-conditioning in Brain Injury Induced by Myocardial IR on Inflammatory Factor and GFAP / 现代生物医学进展
Progress in Modern Biomedicine
;
(24): 5206-5209, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-615247
ABSTRACT
Objective:
To evaluate the effect of post-conditioning in brain injury induced by myocardial I/R on inflammatory factor and GFAP.Methods:
Male Sprague-Dawley rats were randomly allocated into 3 groups (n=8)group Sham,group IR,group IPost.Myocardial IR was induced by occlusion of the anterior descending branch of the left coronary artery for 30 min.group IPost received 3 cycles of 10 s reperfusion followed by 10 s ischemia at the end of myocardial ischemia.The rats were sacrificed at 120 rain of reperfusion and the brains were removed for microscopic examination,inflammatory factors and GFAP.Results:
Compared with group Sham,IL-6,IL-8 were significantly increased,IL-10 was down-regulated in group IR(P<0.01).Post-conditioning can decrease IL-6,IL-8 and up-regulated IL-10(P<0.01).When compared with group Sham,the expression of GFAP was higher in group IR(P<0.05),however,the GFAP in group IPost is the most among these three groups(P<0.01).Conclusion:
Post-conditioning could protect brain by decreasing inflammatory factors,increasing GFAP,which both from brain injury induced by myocardial ischemia reperfusion.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Progress in Modern Biomedicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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