Adverse Reaction to Methotrexate and Etretinate in a Patient with Psoriasis
Annals of Dermatology
;
: 59-63, 1989.
Artigo
em Inglês
| WPRIM
| ID: wpr-61542
ABSTRACT
A 49-year-old Caucasian male patient suffered from fever general weakness and diffuse hair loss on the scalp for 3 days. Skin lesions showed erythematous scaly patches with pustules and erosions on the lower extremities and perianal region, and multiple ulcerations on the labial mucoas. A complete blood cell count revealed thrombocytopenia and leukopenia, which gradually worsened day after day (platelet 29, 000/mm², WBC 1,000/mm³). Candida albicans was isolated from the lesions of the oral cavity and lower extremities. Twelve days prior to the visit, he had taken etretinate Tegison®) P.O.25mg/day, prednisolone P.O. 50mg1dy and methotrexate P.O. 15mg/day for 5 days for the treatment of psoriasis. We presume that these adverse reactions may be synergistic adverse reactions, probably due to methotrexate and etretinate in consideration of the patient's history.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Psoríase
/
Couro Cabeludo
/
Pele
/
Trombocitopenia
/
Úlcera
/
Contagem de Células Sanguíneas
/
Candida albicans
/
Prednisolona
/
Etretinato
/
Metotrexato
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
1989
Tipo de documento:
Artigo
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