Function of leptin in gallstone formation / 国际外科学杂志

ABSTRACT

Objective To investigate the function of serum and bile leptin in the formation of gallstones.Methods Patients were divided into two groupsgallbladder cholesterol gallstone group (group A,n =58) and non-gallstone group (group B,n =33).With a body mass index of 24 kg/m2 for the standard,the group A was also divided into the group A1 (body mass index ≥24 kg/m2,n =30) and group A2 (body mass index ＜ 24 kg/m2,n =28).Group B was divided into group B1 (body mass index≥24 kg/m2,n =18) and group B2 (body mass index ＜24 kg/m2,n =15).Fasting blood samples from all study participants were assayed for total bile acid,total cholesterol,triglyceride,low density lipoprotein,high density lipoprotein,apolipoprotein AI,apolipoprotein B,lipoprotein (a).Serum leptin and bile leptin were measured using an enzyme-linked immunosorbent assay.Results A total of 58 patients with gallbladder cholesterol gallstone and 33 controls were included in the study.The serum level of leptin,total cholesterol,low density lipoprotein,apolipoprotein B and triglyceride were significantly increased,high density lipoprotein and apolipoprotein AI significantly decreased in patients with gallbladder cholesterol gallstone compared with controls(P ＜0.05).While bile leptin,total Bile acid,lipoprotein(a) were no significant difference between group A and group B (P ＞ 0.05).Serum leptin in patients with gallbladder cholesterol gallstone were significantly positively correlated with Body Mass Index(r =0.65,P =0.01),Especially when Body Mass Index ≥ 24 kg/m2 (r =0.73,P ＜ 0.01).Conclusions Changes in levels of serum leptin may affect levels of blood lipid,some lipoprotein and bile leptin,then promote the formation of cholesterol stones.