Effect of Intrauterine and Progesterone Sustained-release System Assisted Ablation on Estrogen and Progesterone Receptor Expression in Patients with Adenomyosis / 医学研究杂志

ABSTRACT

Objective To investigate the effect of assisted excision of intrauterine progesterone (PR) on different hormone levels and expression of receptor in patients with adenomyosis.Methods Totally 84 patients with adenomyosis admitted in our hospital from January 2015 to June 2016 were randomly divided into control group and experimental group according to different treatment methods.In the control group,40 cases were treated with focal lesion 44 cases were treated with adenosine and progesterone sustained-release system.The therapeutic effect was evaluated by the expression of estrogen and progesterone receptor in the two groups after treatment.The therapeutic effects were compared between the two treatment methods The advantages and disadvantages.Results VAS and PBAC score before and after treatment in the two groups were compared.The VAS of the two groups before and after treatment was no significant difference and VAS grading had no difference(P ＞0.05).1,3 and 6 months after treatment in the two groups VAS and VAS grading were different in different degree,P ＜ 0.05.There was no significant difference in the ER and PR levels between the control group and the experimental group before and after treatment (P ＞ 0.05).The levels of ER and PR in the endometrium were significantly lower than those in the control group (P ＞ 0.05).The level of ER and PR in the control group was significantly higher than that in the control group (P ＜ 0.05),and there was no significant difference between the control group and the experimental group (P ＞ 0.05).The levels of FSH and LH in the two groups were significantly lower than those before treatment (P ＜ 0.05),and the difference was significant (P ＜ 0.05).The difference of the levels of FSH between the two groups was statisticaliy significant (P ＜ 0.05),and PGF2α and TXA2 in patients,the two groups were lower than before treatment,and the difference was statistically significant(P ＜ 0.05).Conclusion Ectopic pregnancy and progesterone assisted resection of adenocarcinoma has a good effect on adenomyosis.It can not only improve the clinical symptoms,but also improve the expression of estrogen and progesterone.It is suitable for clinical application.