Short term treatment of uncomplicated falciparum malaria in Sierra Leone West Africa / 实用医学杂志

ABSTRACT

Objective To explore the short term treatment and highly effective treatment strategy for uncomplicated falciparum malaria in West Africa. Methods A total of 188 cases with uncomplicated falciparum malaria in the 34 Military Hospital in Sierra Leone and the tropical infectious disease prevention and control center of Chinese People′s Liberation Army and Sierra Leone Armed Forces from August 2016 to December 2016 were studied. All the patients were randomly divided into observation group A ,B and control group. Patients in group A were treated with oral artemether-lumefantrine tablets for 3 days,and the patients in group B were treated with oral dihydroartemisinin-piperaquine phosphate tablets for 2 days,while the control group patients received oral dihydro-artemisinin-piperaquine phosphate tablets for 7 days. The clinical efficacy ,recrudescence rate and adverse reaction were compared. Results The curative rates of observation group A ,B and the control group after the first course of treatment were 93.6%,95.2%,95.1%respectively,but there was no significant difference between groups(P>0.05). Recrudescence rate of group A was higher than that of the group B and the control group after 8 weeks follow-up,but the difference between groups was not statistically significant(P > 0.05). The incidence of drug adverse reaction in group A was the lowest among three groups ,and the difference was statistically significant compared with that of control group(P < 0.05). More patients in the control group manifested abnormal liver function with mild increased alanine aminotransferase level compared with patients in other groups at the end of treatment course. Conclusion Effectiveness of short term treatment with dihydroartemisinin-Piperaquine phosphate and Artemether-lumefantrine is obvious with lower adverse drug reaction in treating West Africa patients with uncomplicated falci-parum malaria.