Action mechanisms of continuous renal replacement therapy for sepsis / 医学研究生学报

ABSTRACT

Sepsis is a life-threatening organ dysfunction caused by dysregulated immune response to infection, which has high rates of morbidity and mortality.The imbalance between the response to inflammation and that to anti-inflammation is one of the most important pathophysiological processes in patients with sepsis.Despite the variety of its treatment options, their therapeutic effects remain unsatisfactory.Continuous renal replacement therapy (CRRT) is gaining a wider application in critical care medicine, especially in the treatment of sepsis, which can significantly increase the survival rate of sepsis patients by immunity modulation, organ support, and internal environment stabilization, so as to improve the immune disorder, protect the organ functions, and maintain homeostasis in the body.