Quantitative expression of CD147, MMP-9 and VEGF in lung adenocarcinoma and their clinical significance / 临床与实验病理学杂志

ABSTRACT

Purpose To investigate the expression of CD147,MMP-9 and VEGF and their relationships in lung adenocarcinoma.Methods The expression of CD147,MMP-9 and VEGF proteins was examined in 90 lung adenocarcinoma tissues by SP immunohistochemical method.The positive unit (PU) of CD147,MMP-9 and VEGF was assessed quantitatively using Imagepro Plus image analysis software.Results Positive intensity of CD147,MMP-9 and VEGF in lung adenocarcinoma was significantly higher than that in non-neoplastic internal controls and benign control tissues (P ＜ 0.001).The positive rates of CD147,MMP-9 and VEGF were 88.89％ (80/90),84.44％ (76/90),and 80％ (72/90),respectively.The expression of CD147,MMP-9 and VEGF was positively correlated with the degree of histologic differentiation,lymph node metastasis status and TNM stage (P ＜ 0.001).CD147 was correlated positively with MMP-9 and VEGF expression (rp =0.992,rp =0.984,P ＜ 0.001).Conclusion CD147,MMP-9 and VEGF may play an important role in the pathogenesis and progression of lung adenocarcinoma;CD147 may induce tumor invasion and metastasis by stimulating production of MMP-9 and VEGF,which is expected to be a potential promising target for immunotherapy.