Cleft lip and cleft palate in Jangxi province: A case-control study on familial occurrence of 1 967 cases / 实用口腔医学杂志
Journal of Practical Stomatology
; (6): 712-717, 2016.
Article
em Zh
| WPRIM
| ID: wpr-618600
Biblioteca responsável:
WPRO
ABSTRACT
Objective:To assess whether familial occurrence has an influence on the morphological characteristics of patients with nonsyndromic cleft lip and/or palate (NsCL/P).Methods:A case-control analysis was performed on the morphological characteristics of familial group and sporadic group,using medical records of 1967 patients with NsCL/P treated in the Affiliated Stomatological Hospital of Nanchang University from 2002 to 2014.Results:164 (8.34%) cases presented a positive history of cleft in their families.The cleft types,the positive familial rate of cleft lip only (CLO),cleft lip and alveolar ridge(CLA),cleft lip and palate (CLP) and cleft palate only (CPO) were 8.11%,8.54%,6.19% and 9.65% respectively.A positive family history of NsCL/P was associated with 0.66 times risk of CPO (P =0.036,OR =0.66,95% CI 0.44-0.98) compared to those of CLO,CLA and CLP.In familial group of CLP,the lateral incidence of male patients was different from that of female patients (P < 0.001).There was no significant difference between familial group and sporadic group on birth weights,parental child-bearing age and clinical manifestations of patients.Conclusion:Familial occurrence might have an influence on cleft type,laterality and gender of the patients with NSCL/P.
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WPRIM
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
Journal of Practical Stomatology
Ano de publicação:
2016
Tipo de documento:
Article