Study on Compatible Stability of Voriconazole for Injection Combined with 2 Kinds of Injections / 中国药房
China Pharmacy
;
(12): 2343-2346, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-619057
ABSTRACT
OBJECTIVE:
To investigate the compatible stability of Voriconazole for injection after mixed with Fructose injec-tion or Invert sugar injection.METHODS:
Referring to package inserts,Voriconazole for injection 200 mg was dissolved with Wa-ter for injection to 20 mL,and then combined with Fructose injection 250 mL and Invert sugar injection 250 mL,respectively. At room temperature,the appearance of mixtures were observed 0,1,2,3,4,5 h after mixing,and pH value and the number of in-soluble particles were determined;the content of voriconazole was determined by HPLC.RESULTS:
Under above condition,the appearance and pH value of mixtures had no significant change within 5 h;the number of particles ≥10 μm and ≥25 μm were all in line with the standard of Chinese Pharmacopoeia (2015 edition);the relative content of voriconazole was decreasing (95.28%-100%),but it changed within ±5%(RSD<2%,n=6).CONCLUSIONS:
Voriconazole for injection could keep stable within 5 h after mixed with Fructose injection or Invert sugar injection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2017
Tipo de documento:
Artigo
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