Predictive value of peripheral blood neutrophil and lymphocyte ratio in patients withhypertension and cardiovascular events in patients with hypertension / 国际检验医学杂志

ABSTRACT

Objective To investigate the predictive value of peripheral blood neutrophil to lymphocyte ratio(N/L ratio) in patients with hypertension.Methods A total of 660 cases hypertension patients were enrolled from May 2013 to May2014.Peripheral blood N/L ratio was recorded.All patients were followed up to May 31,2016.According to the incidence of cardiovascular and cerebrovascular events,all patients divided into observation group(with cardiovascular and cerebrovascular events) and control group(without cardiovascular and cerebrovascular events),and white blood cell classification was compared.Logistic regression model was used to evaluate the value of N/L to predict cardiovascular events.Results The incidence rates of smoking,diabetes and hyperlipidemia in patients of the observation group were 87.5%,72.5% and 77.5%,higher than those of the control group(P<0.05),and the level of mean arterial pressure(MAP) was(95±12) mmHg,significantly higher than the control group(P<0.05).White blood cell count,percentage of neutrophils,mononuclear cell count,N/L of observation group were(11.6±2.5)×109/L,(70.8±5.9)%,(8.3±5.5)% and 3.7±1.5 were higher than control group(P<0.05).N/L increased by 10%(P=0.04),MAP increased by 10 mmHg(P=0.02) and the proportion of neutrophils(N%) increased by 15%(P=0.03) were independent risk factors for death in patients.Conclusion Neutrophil/lymphocyte ratio and mean arterial blood pressure were independent risk factors for hypertension patients with West-to-cerebral vascular events.