Influence of budesonide combined with montelukast on lung function and transforming growth factor-β1 of children with cough variant asthma / 药物评价研究

ABSTRACT

Objective To investigate the clinical efficacy of budesonide combined with montelukast on treatment of children with cough variant asthma,and its influence on lung function and transforming growth factor-βl.Methods One hundred and seventeen children with cough variant asthma inXi'an Central Hospital from August 2013 to June 2016 were divided into control group and observation group.Fifty-nine children in control group were treated with aerosol budesonide,while 58 children in observation group were treated with montelukast based on control group.The lung function index including VC,FEV1,FEV1/FVC,and PEF pred％,TGF-β1,inflammatory factors including IgE,IL-8,TNF-α,and clinical symptom score in both groups were detected and analyzed before and after treatment.Results After two months of treatment,clinical symptom score in each group obviously decreased,and that in observation group was significantly lower than that of control group (P ＜ 0.05).The FEV1,FEV1/FVC,and PEF pred％ of two groups showed remarkable increase,and those in observation group were much higher than those of control group (P ＜ 0.05),while no conspicuous changes were detected in VC.Additionally,TGF-β1 of each group increased markedly,and that in observation group was much higher,while IgE,IL-8,and TNF-αin two groups showed obvious decrease,and those in observation group were significantly lower than those of control group (P ＜ 0.05).Conclusion Budesonide combined with montelukast had a great ability on treatment of children with cough variant asthma,and could significantly improve the lung function and levels of TGF-β1,and inhibit the levels of inflammatory factors.