Clinical effect and influence on congnitive reaction of single use of valproate,oxcarbazepine, and levetiracetam in treatment of children epilepsy / 药物评价研究

ABSTRACT

Objective To explore the clinical effect and influence on congnitive function of single use ofvalproate,oxcarbazepine,and levetiracetam in treatment of children epilepsy.Methods Children with epilepsy (96 cases) accepted in Weinan Matemty and Child Health Care Hospital from April 2011 to January 2016 were randomly divided into groups A,B,and C.Children in those three groups were given valproate,oxcarbazepine,and levetiracetam,respectively.Then the clincial efficacy,changes of EEG and congnitive function,and safety were compared.Results The total effective rates of groups A,B and C were 71.88％,78.13％,and 90.63％,respectively,group C was little higher than groups A and B without statistically significance.The epileptiform discharge improvement rate was getting better following extended therapy.The improvement rate of group C was better than that of group B and even much better than that of group A with statistically significance (P ＜ 0.05).The verbal IQ (VIQ),performance IQ (PIQ),and full scale IQ (FIQ) of three groups before treatment had no big difference,but the scores of groups B and C were much better than before and group A after treatment with statistically significant difference (P ＜ 0.05).The adverse reaction rates of groups A,B,and C were 28.13％,12.50％,and 3.13％,respectively with statistically significant difference among them (P ＜ 0.05).Conclusion Valproate,oxcarbazepine,and levetiracetam have similar effect in treatment of children epilepsy,but oxcarbazepine and levetiracetam have positive significance in EGG and recognition function improvement.And the safety of levetiracetam is the highest of three drugs,which is worth of clincial application.