Observation on the effect of venlafaxine combined with antipsychotics on the treatment of negative symptoms of schizophrenia / 中国生化药物杂志

ABSTRACT

Objective To investigate the effect of venlafaxine combined with antipsychotic drugs in the treatment of negative symptoms of schizophrenia.Methods In this study, 60 patients with schizophrenia who were treated and diagnosed in ankang hospital of Hangzhou public security bureau from June 2015 to November 2016 were randomly divided into the experimental group and the control group according to the time of admission.The control group was only given antipsychotic(risperidone);enrolifloxacin combined with antipsychotics(risperidone)was used in the experimental group.The patients were evaluated with the positive and negative symptoms scale, and the side effects were assessed by the Adverse Reaction Symptom Scale(TESS).A 12-week study was conducted.Results Compared with the results of this experiment, the scores of PANSS and the scores of the two groups were not different between the two groups before and after treatment.4,8,12 weekend negative group of experimental group and the difference was very significant before treatment;8,12 weekend negative control group score and before treatment is relatively poor.There were significant differences in negative factor scores between the two groups at 4, 8 and 12 weeks.There was significant difference between the two groups (P<0.05).Conclusion Risperidone combined with venlafaxine is effective in the treatment of schizophrenia with negative symptoms.It has good curative effect and high safety.It is worth popularizing in clinic.