Notch signaling pathway and bronchiolitis / 国际儿科学杂志

ABSTRACT

Bronchiolitis is the most common lower respiratory tract infection in infancy and early childhood.The main pathogen is respiratory syncytial virus (RSV),which is one of the main factors in hospitalized infants,closely related to asthma.However,the detailed mechanism is not clarified,and there is no specific treatment.Recent studies have showed that Notch signaling pathway plays an important role in its pathogenesis.This review mainly summarizes the association between bronchiolitis immunological mechanisms and Notch siganling pathway.