The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor
Malaysian Journal of Medical Sciences
;
: 94-99, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-625461
ABSTRACT
in the mammalian cortex and hippocampus. It is expressed heterologously in the Xenopus laevis oocyte as a α1β2γ2S/L subtype for application as an in vitro model for the screening of compounds that modulate receptor activities. In fact, 4-hydroxybenzaldehyde (4-HB) has been identified as one of the major components in Dendrocalamus asper bamboo shoots in our previous study, and the current study showed that at 101.7 μM, 4-HB significantly reduced the GABA-induced chloride current of GABAA receptors expressed on Xenopus oocytes, indicating a possible GABAergic antagonistic effect at high concentrations.
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WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Malaysian Journal of Medical Sciences
Ano de publicação:
2017
Tipo de documento:
Artigo
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