Metabolic and Immunologic Alterations of Ginger Rhizome among Streptozotocin-Nicotinamide Induced Diabetic Rats
Malaysian Journal of Nutrition
;
: 421-432, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-625544
ABSTRACT
This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Methods:
Forty-eight fasted male Sprague-Dawley rats were induced diabetes using a single intraperitoneal injection of NA(110 mg/kg b.w.) and STZ (65 mg/kg b.w, 15 min after NA). Diabetic rats orally received either different concentrations (250, 500 and 750 mg/kg body weight) of ginger rhizome suspension or glibenclamide (10 mg/kg body weight) for 6 weeks. Two control diabetic and normal groups were gavaged with only distilled water as a vehicle.Results:
The results indicated that the lower concentrations of ginger modulated body weight, fasting blood glucose, level of triglyceride and tumor necrosis factor-a (TNF-a) (p0.05).Conclusion:
Ginger indicated better impact on metabolic and immunologic parameters in lower doses of supplementation compared with high doses of treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Malaysian Journal of Nutrition
Ano de publicação:
2016
Tipo de documento:
Artigo
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