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Clozapine Re-Challenge With Lithium Supplementation Following Clozapine-Induced Neutropenia
ASEAN Journal of Psychiatry ; : 90-92, 2014.
Artigo em Inglês | WPRIM | ID: wpr-626268
ABSTRACT

Objectives:

This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out.

Methods:

The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvement but developed neutropenia. Withdrawal of clozapine brought on a relapse of psychotic symptoms. Subsequently, clozapine was reintroduced along with Lithium. The neutrophil count was monitored closely.

Results:

The neutrophil and white blood cell count were noted to return to normal upon re-challenging, and the patient’s clinical condition also improved.

Conclusion:

Simultaneous administration of lithium and clozapine to patients experiencing neutropenia on clozapine is a possible strategy. However, very close monitoring of the white count is needed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Esquizofrenia / Clozapina / Lítio / Neutropenia Idioma: Inglês Revista: ASEAN Journal of Psychiatry Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Esquizofrenia / Clozapina / Lítio / Neutropenia Idioma: Inglês Revista: ASEAN Journal of Psychiatry Ano de publicação: 2014 Tipo de documento: Artigo