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Detection of Human Herpesvirus 6 (HHV-6) in Saliva of Healthy Adults in Malaysia
Malaysian Journal of Medicine and Health Sciences ; : 55-64, 2012.
Artigo em Inglês | WPRIM | ID: wpr-627477
ABSTRACT

Background:

Human herpesvirus-6 (HHV-6) levels have been considered as markers for various diseases. The aim of this study was to evaluate the prevalence of HHV-6 infection in healthy adults in Malaysia.

Methods:

The level of HHV-6 in saliva was investigated in 36 healthy adults, age 19 to 23 years, at Kuala Lumpur, Malaysia using variant-specific TaqmanTM quantitative real-time PCR (qPCR).

Results:

The amount of HHV-6 DNA in the saliva of healthy adults ranged from negative to 10,000 HHV-6 genomes/ml of saliva (median, 360 genomes/ml of saliva). Of the 36 samples tested, 30 (83%) contained HHV-6 DNA. HHV-6B was the only variant detected in the saliva of all the positive cases.

Conclusions:

The detection of HHV-6 DNA in saliva by real-time PCR assay provides a sensitive and specific quantitation of HHV-6. Our pilot study suggests the wide prevalence of HHV-6 in saliva from healthy adults.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico Idioma: Inglês Revista: Malaysian Journal of Medicine and Health Sciences Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico Idioma: Inglês Revista: Malaysian Journal of Medicine and Health Sciences Ano de publicação: 2012 Tipo de documento: Artigo