Antiepileptic drug trials with greater attention to daily clinical practice and special epilepsy syndromes

ABSTRACT

Most of the present antiepileptic drug trials focus on efficacy and short-term safety with limited information relevant for daily clinical practice, such as spectrum of efficacy, effective dose, titration method, drug interactions, and long-term outcome. Antiepileptic drug trials more akin to daily clinical practice should also be emphasized in future trials. There are, limited randomized control trials for certain seizure types or epilepsy syndromes, such as Lennox-Gastaut syndrome and severe myoclonic epilepsy in infancy. The author proposed self-controlled “class S” study in patients who has well-defined epilepsy syndrome with homogeneity in evolution of illness and high frequency of seizures.