Cryptococcal meningitis in a patient with chronic hepatitis C treated with pegylated-interferon and ribavirin
The Korean Journal of Internal Medicine
;
: 370-374, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-62912
ABSTRACT
Various adverse events have been reported during combination therapy with pegylated (PEG)-interferon-alpha and ribavirin, although opportunistic infections, especially cryptococcal meningitis, are very rare. A 61-year-old woman complained of headaches and a fever during treatment of a chronic hepatitis C virus (HCV) infection. She had been treated for 7 months. Her headaches were refractory to analgesics, and she developed subtle nuchal rigidity. The cerebral spinal fluid (CSF) revealed a white blood cell count of 205/mm3, 51 mg/dL protein, 35 mg/dL glucose, and negative Cryptococcus antigen. The CSF culture resulted in no growth. Five days later, the CSF was positive for Cryptococcus antigen. We administered amphotericin B and flucytosine, followed by fluconazole. Approximately 2 months later, she was discharged. For the first time, we report a case of cryptococcal meningitis during the treatment of chronic HCV with PEG-interferon-alpha and ribavirin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Polietilenoglicóis
/
Ribavirina
/
Fatores de Tempo
/
Infecções Oportunistas
/
Proteínas Recombinantes
/
Resultado do Tratamento
/
Meningite Criptocócica
/
Interferon-alfa
/
Hospedeiro Imunocomprometido
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2014
Tipo de documento:
Artigo
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