Hypertriglyceridemia and Cardiovascular Diseases: Revisited
Korean Circulation Journal
;
: 135-144, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-62942
ABSTRACT
Residual cardiovascular risk and failure of high density lipoprotein cholesterol raising treatment have refocused interest on targeting hypertriglyceridemia. Hypertriglyceridemia, triglyceride-rich lipoproteins, and remnant cholesterol have demonstrated to be important risk factors for cardiovascular disease; this has been demonstrated in experimental, genetic, and epidemiological studies. Fibrates can reduce cardiovascular event rates with or without statins. High dose omega-3 fatty acids continue to be evaluated and new specialized targeting treatment modulating triglyceride pathways, such as inhibition of apolipoprotein C-III and angiopoietin-like proteins, are being tested with regard to their effects on lipid profiles and cardiovascular outcomes. In this review, we will discuss the role of hypertriglyceridemia, triglyceride-rich lipoproteins and remnant cholesterol on cardiovascular disease, and the potential implications for treatment stargeting hypertriglyceridemia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Triglicerídeos
/
Doenças Cardiovasculares
/
Hipertrigliceridemia
/
Estudos Epidemiológicos
/
Ácidos Graxos Ômega-3
/
Colesterol
/
Fatores de Risco
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Apolipoproteína C-III
/
Ácidos Fíbricos
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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