Heterogeneous t(4;11) fusion transcripts in two infants with acute lymphoblastic leukemia
The Malaysian Journal of Pathology
;
: 105-10, 2004.
Artigo
em Malaiala
| WPRIM
| ID: wpr-629549
ABSTRACT
An RT-PCR assay detected the t(4;11) translocation in two infants with acute lymphoblastic leukemia (ALL). Case P76 was a 10-month-old, female infant, who presented with a WBC of 137.4 x 10(9)/l and a pre-pre-B ALL immunophenotype. Case P120 was a 6-month-old female infant, with a WBC > 615 x 10(9)/l and a pre-pre-B ALL immunophenotype. RT-PCR of cDNA from both these cases generated a 656 bp and a 542 bp respectively, which sequencing confirmed as t(4;11) fusion transcripts. The primers and conditions selected for this assay are compatible with a one-step multiplex PCR for the main translocations in childhood ALL.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Idioma:
Malaiala
Revista:
The Malaysian Journal of Pathology
Ano de publicação:
2004
Tipo de documento:
Artigo
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