In vivo chromosome aberration test for hydroxyapetite in mice
The Medical Journal of Malaysia
;
: 115-116, 2004.
Artigo
em Malaiala
| WPRIM
| ID: wpr-629941
ABSTRACT
This study evaluates the cytotoxic and mutagenic effect of synthetic hydroxyapatite granules (source School of Material and Mineral Resources Engineering, Universiti Sains Malaysia) in the bone marrow cells of mice. Mice are exposed to synthetic hydroxyapatite granules, the bone marrow cells are collected and observed for chromosome aberrations. No chromosome aberrations were noticed in the animals exposed to distilled water (negative control) and to the test substance, synthetic hydroxyapatite granules (treatment) groups. Chromosome aberrations were observed in the animals exposed to Mitomycin C (positive control group). There was no indication of cytotoxicity due to synthetic hydroxyapatite granules in the animals as revealed by the mitotic index. Hence, synthetic hydroxyapatite granules are considered non-mutagenic under the prevailing test conditions.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células da Medula Óssea
/
Aberrações Cromossômicas
/
Durapatita
/
Substitutos Ósseos
/
Testes de Mutagenicidade
Idioma:
Malaiala
Revista:
The Medical Journal of Malaysia
Ano de publicação:
2004
Tipo de documento:
Artigo
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