Changes in Corpus Cavernosum after Partial Bladder Outlet Obstruction in Rat / 대한비뇨기과학회지
Korean Journal of Urology
;
: 160-167, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-63091
ABSTRACT
PURPOSE:
Abnormalities of the relaxation and contraction of the corpus cavernosum can lead to erectile dysfunction. Therefore, we induced a partial bladder outlet obstruction(PBOO) in male rats, and investigated the mechanisms of penile dysfunction with endothelial nitric oxide synthase(eNOS), vascular endothelial growth factor(VEGF), endothelin-1(ET-1), and apoptosis of peri-vascular smooth muscle and connective tissue cells in the corpus cavernosum. MATERIALS ANDMETHODS:
PBOO was induced in 13 Sprague-Dawley rats by placing a 25 gauge needle sheath around the urethra, then ligating the bladder neck with a 3-0 suture. Three week after surgery, distal penile tissues were dissected for immunohistochemical staining, immunoblotting, and TUNEL staining.RESULTS:
The expression of eNOS and VEGF were significantly decreased, whereas the expression of ET-1 and apoptosis of perivascular smooth muscle and connective tissue cells were significantly increased in the corpus cavernosum.CONCLUSIONS:
The significant increase of ET-1 and apoptosis along with decreased eNOS and VEGF could mediate erectile dysfunction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Relaxamento
/
Suturas
/
Uretra
/
Bexiga Urinária
/
Obstrução do Colo da Bexiga Urinária
/
Immunoblotting
/
Ratos Sprague-Dawley
/
Apoptose
/
Células do Tecido Conjuntivo
/
Endotelina-1
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
2008
Tipo de documento:
Artigo
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