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Prophylactic intravenous ketorolac for prevention of intraventricular hemorrhage in preterm infants ? 32 weeks and < 1500 grams: A double-blind, randomized, placebo-controlled trial
Acta Medica Philippina ; : 70-74, 2016.
Article em En | WPRIM | ID: wpr-632846
Biblioteca responsável: WPRO
ABSTRACT
@#<p style="text-align: justify;">Intraventricular hemorrhage (IVH) remains an important cause of morbidity and mortality in Very Low Birth Weight (VLBW) infants. Since 2004, Indomethacin, which is effective in preventing IVH, has been removed from the Philippine market. Ketorolac is a nonselective cyclooxygenase inhibitor which is structurally-related and of equal potency to Indomethacin.<br /><strong>OBJECTIVE:</strong> This study aims to determine if prophylactic ketorolac compared to placebo will decrease IVH and its associated morbidities among preterm neonates.<br /><strong>METHODS:</strong> We conducted a double-blind, randomized, placebo-controlled trial among neonates born in a tertiary government university hospital. Newborns with gestational age ?32 weeks and birth weight <strong>RESULTS:</strong> A total of 134 infants were included in this study. There was no difference in the proportion of infants who developed IVH between the ketorolac and placebo groups (46% vs. 45%). The mean serum creatinine levels were significantly higher in the ketorolac group (1.15 ± 0.69 vs 0.79 ±0.38; p=0.002). The rates of death, sepsis, necrotizing enterocolitis, bleeding, platelet counts of <50,000/mm3, mean urine output and the lengths of hospital stay were similar in the two groups.<br /><strong>CONCLUSION:</strong> Prophylactic intravenous ketorolac was ineffective in preventing IVH among preterm infants. Ketorolac cannot be recommended for the prevention of IVH.</p>
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Índice: WPRIM Assunto principal: Filipinas / Contagem de Plaquetas / Peso ao Nascer / Ecoencefalografia / Hemorragia Cerebral / Idade Gestacional / Inibidores de Ciclo-Oxigenase / Sepse / Creatinina Tipo de estudo: Clinical_trials Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Acta Medica Philippina Ano de publicação: 2016 Tipo de documento: Article
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Índice: WPRIM Assunto principal: Filipinas / Contagem de Plaquetas / Peso ao Nascer / Ecoencefalografia / Hemorragia Cerebral / Idade Gestacional / Inibidores de Ciclo-Oxigenase / Sepse / Creatinina Tipo de estudo: Clinical_trials Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Acta Medica Philippina Ano de publicação: 2016 Tipo de documento: Article