Generalized asymptomatic red nodules in a 21-year old Filipino male
Journal of the Philippine Dermatological Society
;
: 71-73, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-632987
ABSTRACT
A 21 year old Filipino male presented with swelling of the second right hand digit unresponsive to antibiotics. Amputation revealed chronic inflammation and negative cultures. He developed sterile conjunctivitis and a generalized eruption of asymptomatic red papules and nodules. First skin biopsy revealed a diffuse infiltrate of epithelioid and foamy histiocytes, diagnosed as "juvenile xanthogranuloma." The second biopsy revealed large histiocytes with a "ground-glass" eosinophilic cytoplasm, multinucleated giant cells, and mixed cell infiltrate. Immunohistochemistry showed histiocytes staining with (+)S100 and (+)CD68, and (-)CD1a. Final diagnosis was "multicentric reticulohistocytosis." Despite treatment with oral prednisone, methotrexate and alendronate, lesions were progressive. CONCLUSION:
This fascinating case manifests with overlapping features of both juvenile xanthogranuloma and multicentric reticulohistiocytosis, and lead the authors to suggest considering the spectrum of diseases called the non-Langerhans cells histiocytosis when presented with a generalized nodular eruption.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Biópsia
/
Células Gigantes
/
Histiocitose de Células não Langerhans
/
Metotrexato
/
Conjuntivite
/
Antígenos CD1
/
Exantema
/
Histiócitos
/
Inflamação
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of the Philippine Dermatological Society
Ano de publicação:
2008
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS