A pilot study on the effect of statins, fibrates and its combination in rat nerves
Philippine Journal of Neurology
; : 1-5, 2004.
Article
em En
| WPRIM
| ID: wpr-633186
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To determine the histopathological effect of statins, fibrates and its combination in rat nervesMETHODOLOGY: This is a pilot experimental study. Four male albino rats were used in this study. Each rat was given therapeutic doses of simvastatin alone, gemfibrozil alone, gemfibrozil and simvastatin combination and placebo. On day 21, the sciatic nerve was harvested for histopathologic examinationRESULTS: Although not marked, the combination of simvastatin and gemfibrozil produced more axonal degeneration than did simvastatin alone or gemfibrozil alone. Axonal degeneration was documented on teased nerve fibers and epon cross sectionsCONCLUSION: The use of lipid lowering agents may induce peripheral neuropathy Recommendation: This pilot study serves as rationale to proceed with an experiment not only to document neuropathy but also correlate the possible association of the pathomechanism of myotoxicity and neurotoxicity of lipid lowering agents.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Nervo Isquiático
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Genfibrozila
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Doenças do Sistema Nervoso Periférico
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Inibidores de Hidroximetilglutaril-CoA Redutases
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Sinvastatina
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Resinas Epóxi
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Ácidos Fíbricos
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Animais
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Fibras Nervosas
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Hipolipemiantes
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Revista:
Philippine Journal of Neurology
Ano de publicação:
2004
Tipo de documento:
Article