Early Marker of Myocardial Deformation in Children with Duchenne Muscular Dystrophy Assessed Using Echocardiographic Myocardial Strain Analysis
Yonsei Medical Journal
;
: 900-904, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-63334
ABSTRACT
PURPOSE:
As cardiomyopathy is more prevalent and currently the leading cause of death in Duchenne muscular dystrophy (DMD), early detection of myocardial involvement is important. The purpose of this study was to analyze myocardial strain in DMD children, for the possibility of early detection of myocardial dysfunction. MATERIALS ANDMETHODS:
We reviewed medical records of DMD patients who were >10 years of age (15.6±1.6 years, 12.5-18 years), from March 2013 to June 2014. Data of 24 DMD children who underwent echocardiography with three-layer specific myocardial strain were compared with 24 controls (age 9.3±4.0 years, 5.5-17 years).RESULTS:
Epicardial longitudinal strain was lower in DMD (DMD -9.3±3.8%; control -12.3±4.3%; p=0.012). Radial strain (DMD 24.1±11.1%; control 37.3±25.9%; p=0.027) and strain rate (SR) (DMD 1.68±0.91; control 2.42±0.84; p=0.006) on parasternal short axis view were lower in DMD. Circumferential strains in the endocardium (DMD -17.5±4.7%; control -24.2±5.3%; p<0.001), myocardium (DMD -12.7±3.8%; control -18.0±4.0%; p<0.001), and epicardium (DMD -8.4±4.0%; control -12.2±5.0%; p=0.006) were significantly decreased in DMD. Circumferential SRs were lower in the endocardial (DMD -1.46±0.38; control -1.78±0.27; p=0.002) and myocardial layers (DMD 1.02±0.27; control -1.28±0.22; p=0.001).CONCLUSION:
In DMD patients, deteriorations in myocardial circumferential strain might be an indicator for predicting cardiomyopathy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ecocardiografia
/
Estudos de Casos e Controles
/
Valor Preditivo dos Testes
/
Distrofia Muscular de Duchenne
/
Diagnóstico Precoce
/
Cardiomiopatias
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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