Safety and effectiveness of insulin lispro mix 25/75 among Filipino patients with type 1 or type 2 diabetes mellitus: A post-marketing surveillance study
Philippine Journal of Internal Medicine
;
: 1-8, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-633421
ABSTRACT
BACKGROUND:
Diabetes mellitus (DM) is a major cause of morbidity and mortality in the Philippines. Improvement in hemoglobin A1c (HbA1c) remains below recommended targets for Filipino patients. Safe and effective therapies are needed for this population.OBJECTIVE:
To investigate treatment-emergent adverse events (TEAEs) and change in HbA1c among Filipino patients with DM treated with insulin lispro mix 25/75 in a real-world setting.MATERIALS ANDMETHODS:
This was a prospective, non-interventional, post-marketing surveillance study among 459 Filipinos aged 18 years or older with type 1 or 2 DM. Patients were treated with insulin lispro mix 25/75 according to the approved label, as prescribed by the investigators, and observed for 12 weeks. Occurrence of all TEAEs and change in HbA1c from baseline to final visit were reported.RESULTS:
Mean (SD) treatment duration was 12.93 (5.7) weeks, and mean total daily dose was 0.62 (0.29) units/kg. Eighteen patients (3.9%) experienced 23 TEAEs, the majority of which were mild. None were reported to be related to treatment. No serious TEAEs or hypoglycemic episodes were reported. Mean (95% confidence interval) HbA1c was significantly reduced by -2.03% (-2.19%, -1.87%), and 36.3% of patients achieved HbA1cCONCLUSION:
In this observational study, no treatmentrelated safety signals using insulin lispro mix 25/75 were detected among Filipino diabetic patients. HbA1c was significantly reduced in Filipino patients with DM at 12 weeks.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hemoglobinas Glicadas
/
Diabetes Mellitus
/
Insulina Lispro
/
Hipoglicemia
/
Hipoglicemiantes
Tipo de estudo:
Estudo observacional
/
Estudo de rastreamento
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Philippine Journal of Internal Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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