Hungry bone syndrome (HBS) in patients operated for primary hyperparathyroidism (PHPT): A six-year experience
Philippine Journal of Otolaryngology Head and Neck Surgery
;
: 11-16, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-633702
ABSTRACT
OBJECTIVE:
To review cases of adult patients who develop Hungry Bone Syndrome (HBS) after parathyroidectomy for Primary Hyperparathyroidism (PHPT) in a tertiary care center in the Philippines and describe the clinical features, pre-operative preventive measures done and risk factors for HBS.METHODS:
Design:
Retrospective Case Note ReviewSetting:
Tertiary Private HospitalParticipants:
Chart review of adult Filipino patients who underwent parathyroidectomy for PHPT at Makati Medical Center from January 2011 to December 2016 was conducted and evaluated according to the inclusion and exclusion criteria. Medical information obtained included clinical parameters, biochemical results, operation performed, pathology, length of hospital stay and complications if with any.RESULTS:
From among 20 adult Filipino patients (mean age 55 years; 13, 65% female) who underwent parathyroidectomy for PHPT, HBS was found in 7 (35%). Most common pre-operative symptoms of hypercalcemia were musculoskeletal complaints. To prevent HBS, all were hydrated prior to surgery while some were given bisphosphonates and diuretics. The most common parathyroid gland imaging used for pre-procedure localization was Tc 99m Sestamibi scan with single photon emission computed tomography (SPECT) and 19 (95%) had parathyroid adenoma on post-operative histopathologic report. Among biochemical and clinical factors that may be risk factors for HBS, those with HBS had significantly lower pre-operative 25-hydroxyvitamin D, higher BUN, phosphate and alkaline phosphatase (ALP) than those without HBS. Of these, only ALP showed significant association with HBS (OR = 107.17, p =CONCLUSION:
Knowledge on post-parathyroidectomy HBS for PHPT may aid clinicians on preoperative prevention and post-operative monitoring. Thirty-five percent (7) of our patients presented with HBS post-parathyroidectomy for PHPT from 2011 to 2016. An abnormal ALP level pre-operatively may be a risk factor in developing HBS post-parathyroidectomy for PHPT
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias das Paratireoides
/
Glândulas Paratireoides
/
Vitamina D
/
Nitrogênio da Ureia Sanguínea
/
Calcifediol
/
Paratireoidectomia
/
Difosfonatos
/
Diuréticos
/
Fosfatase Alcalina
/
Hiperparatireoidismo Primário
Tipo de estudo:
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Philippine Journal of Otolaryngology Head and Neck Surgery
Ano de publicação:
2017
Tipo de documento:
Artigo
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