High sensitivity CRP and short-term cardiovascular risk among patients with acute myocardial infraction: A two-canter study

ABSTRACT

OBJECTIVE: To determine high sensitivity C-reactive protein (hsCRP) levels of patients admitted for myocardial infarction (MI) and determine its association with existing traditional cardiovascular (CV) risk factors and future cardiovascular events. METHODS: This was a prospective cohort study involving two centers, the Makati Medical Center and the University of the Philippines-Philippine General Hospital (UP-PGH). A total of 49 acute Ml patients who fulfilled the inclusion and exclusion criteria were enrolled in the study. Levels of hs-CRP were taken within 6 hours of admission. Demographic data, in-patient outcomes and 30-day clinical outcomes were observed. A univariate analysis with Fisher's Exact Test was done to determine if there was an association between hs-CRP levels and traditional CV risk factors, and clinical outcomes. RESULTS: There was a significantly higher difference in the primary composite endpoint of all-cause mortality, Ml, unstable angina and revascularization among patients with hs-CRP> 10 mg/dL(CI 95%, p=0.045) CONCLUSION: The study shows that elevated levels of hs-CRP can be utilized for cardiovascular risk stratification and prognostication among patients with acute myocardial infarction.