Successful Erythropoietin Therapy after Alemtuzumab and Cyclosporin a Treatment for Epoetin-Induced Pure Red Cell Aplasia / 대한내과학회지
Korean Journal of Medicine
; : 214-217, 2013.
Article
em En
| WPRIM
| ID: wpr-63513
Biblioteca responsável:
WPRO
ABSTRACT
Pure red cell aplasia (PRCA) in adults is usually idiopathic, although some underlying conditions can cause PRCA. Immunosuppressive therapy (IST) is used to treat PRCA, but IST has side effects and may fail. The anti-CD52 monoclonal antibody alemtuzumab (ALM) was recently used to successfully treat therapy-resistant PRCA. We herein report successful treatment of secondary PRCA after erythropoietin therapy using ALM and cyclosporin A (CsA) in one patient. The total dose of ALM was 60 mg over 3 days (10, 20, and 30 mg, respectively) plus CsA for at least 6 months. The patient achieved a complete response 18 months after ALM-CsA treatment and his treatment could be changed to a different erythropoietin-stimulating agent.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Eritropoetina
/
Ciclosporina
/
Aplasia Pura de Série Vermelha
/
Anticorpos Monoclonais Humanizados
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Korean Journal of Medicine
Ano de publicação:
2013
Tipo de documento:
Article