The Relationship Between the Expression ofMetalloproteinase- 2 and Laryngeal Squamous Cell Carcinoma / 上海第二医科大学学报
Journal of Shanghai Jiaotong University(Medical Science)
;
(6): 418-420, 2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-635261
ABSTRACT
Objective To study the relationship between the expression of matrix metallopro-teinase- 2(MMP- 2) and the clinical pathological characteristics of laryngeal squamous cell carcinoma.Methods Irnmunohistochemistry technique (ABC) was used to detect the expression and location ofMMP- 2 in the tissue of 43 cases with laryngeal squamous cell carcinoma. ResultsThe positive ex-pression rate of the MMP - 2 protein was 29(67.4% ) among the 43 laryngeal tumor tissues. It was sig-nificantly related to metastasis of the cervical lymph nodes (P<0.05). MMP- 2 was immunolocalizedon the membranes and intracytoplasm of metastatic cluster tumor cells or the tumor cells adjacent to thebasement membrane. ConclusionThese results suggest that MMP- 2 plays an important role in thetumor invasion and metastasis of laryngeal squamous cell carcinoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Shanghai Jiaotong University(Medical Science)
Ano de publicação:
2000
Tipo de documento:
Artigo
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