db/db mouse and diabetic retinopathy / 中华实验眼科杂志

ABSTRACT

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes,the incidence increased year by year,so the research of pathogenesis and interventions of DR is in the ascendant.The mechanism of DR mainly include glucose toxicity products and its effects on cell signaling pathways,leading to vascular disease and neuropathy.Research shows that,DR may occur with actived polyol pathway,increased,oxidative stress,the formation of advanced glycation end products (AGEs),protein kinase C pathway and vascular endothelial growth factor (VEGF)expression.db / db mice as an animal model of spontaneous type 2 diabetes,which is very similar to human type 2 diabetes,is more widely used in studies of DR.This article reviews some progresses of db / db mouse in the DR,and provide clues to further elucidate the pathogenesis of DR and development effective preventive measures.