Neutrophil as double-edged swords in fungal keratitis / 中华实验眼科杂志

ABSTRACT

Fungal keratitis is a corneal disease caused by fungal infection with high possibility of blindness,and the morbidity is being higher year by year.Both native immune and adaptive immune are included during antifungi process in which the fungi is killed by native immune especially by neutrophil.The neutrophil kill the fungi not only by oxygen-dependent and oxygen-independent way but also by the neutrophil extracellular traps which is discovered in recent years.The enzyme and reactive oxygen species(ROS) released by the neutrophil are included in the process of fungi killing.But those materials can cause tissue damage which may cause the scar or even corneal perforation.This review mainly focused on the mechanism how the neutrophil kill fungi and cause tissue damage.