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Study on Role of Glutamate Inducing Cortical Neuron Damage in Newborn Rats / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics ; (24)1993.
Artigo em Chinês | WPRIM | ID: wpr-638409
ABSTRACT
Objective To explore the role of glutamate in inducing cortical neuron damage in newborn rats.Methods The model of damage induced by glutamate was established on cultured cortical neurons in newborn rats with primary cultivation technique.To evaluate the severity of neuron injury, the changes of morphology were observed by inverted microscopy, the cell viability and rate of LDH releasing from neuron were detected by MTT assay and biochemical method,respectively;the rate of neuronal apoptosis was measured by flow cytometer system.Results Under the inverted microscopy, neurons showed obvious toxic damage in glutamate treatment group. Compared with controls,the cell viability significantly decreased (t=4.58 P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Applied Clinical Pediatrics Ano de publicação: 1993 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Applied Clinical Pediatrics Ano de publicação: 1993 Tipo de documento: Artigo