The Effect of NK-1 Receptor Antagonist on the Enhanced Response to Bradykinin by Mustard Oil Treatment of the Rat Uterus / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 1325-1331, 2003.
Article
em Ko
| WPRIM
| ID: wpr-63891
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To find out wheather the substance P takes part in the pain mediating system of uterus, and to ascertain the role of substance P in the hypersensitivity of hypogastric nerve to bradykinin during the uterine inflammation. METHODS: The uterus has two sensory innervations, which are the hypogastric nerve and the pelvic nerve. Since the hypogastric nerve is known to show increased sensitivity to bradykinin, a pain mediator, when the uterus is in inflammatory state, the hypogastric nerve recording was done for electrophysiological study of uterine pain-mediating mechanism in female SD rats (200-250 g). NK1 receptor antagonist (L-703,606) was injected through uterine artery before injecting bradykinin while uterus was under inflammation. RESULTS: The NK-1 receptor antagonist (L-703,606) decreased the spontaneous nerve impulse during inflammation, and it also decreased the hypersensitivity of the hypogastric nerve to bradykinin during the uterine inflammation. CONCLUSION: Substance P mediates the pain sense of hypogastric nerve, and it also plays a role in increased sensitivity of hypogastric nerve to bradykinin while uterus is in inflammatory state.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Útero
/
Potenciais de Ação
/
Bradicinina
/
Substância P
/
Negociação
/
Receptores da Neurocinina-1
/
Artéria Uterina
/
Hipersensibilidade
/
Inflamação
/
Mostardeira
Limite:
Animals
/
Female
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2003
Tipo de documento:
Article