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Effect of Intrauterin Hypoxia on Proliferation of Neural Stem Cells and Memory and Learning Capacity of Juvenile Rats / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics ; (24)1986.
Artigo em Chinês | WPRIM | ID: wpr-639505
ABSTRACT
Objective To explore the effect of intrauterin hypoxia on proliferation of neural stem cells(NSCs)and memory and learning capacity of juvenile rats.Methods Conceiving female SD rats(n=20)were divided randomly into 2 groupscontrol group(n=10)and hypoxia group(n=10).The rats of hypoxia group were put into 3 gases incubator to make the injured brain newborn rats model,rats of control group were not done so.The juvenile rats were taken to do the experiment of water maze after they were born in 30 d,then killed when the experiment was over,the brains of the rats were taken,immobilization,paraffin imbedding,slicing(hippocampus),common immunohistochemistry staining were used to detect the Nestin positive NSCs.Results Optical density of Nestin positive cells in hippocampus dentation of hypoxia group(0.16?0.10)was higher than that of control group(0.15?0.09)(t=3.24 P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Applied Clinical Pediatrics Ano de publicação: 1986 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Applied Clinical Pediatrics Ano de publicação: 1986 Tipo de documento: Artigo