Change of Serum Neuroglobin in Newborn Infants with Fetal Distress / 实用儿科临床杂志

ABSTRACT

Objective To observe the change of serum neuroglobin(NGB)of normal full-term and fetal distress infants,and to explore the sensitivity and validity of NGB as potential biomarker for brain injury.Methods The technique of double-antibody sandwich enzyme-linked immunosorbent assay to measure NGB was established,and stable data standard curve was gained.Serum NGB of umbilical cord artery in 35 normal full-term(17 male,18 female)and 32 newborn infants were measured.The differece of serum NGB in gender,and the changes in serum NGB of fetal distress infants were analyzed,who were probably injured by anoxia.The results were analyzed by Stata 7.0 software.Results The standard curvilinear equation was Y=exp(-5.881 532+11.955 890?X)+2.281 506E-02(linear correlation coefficient r=0.999 4 P0.05);the average NGB in the serum of umbilical cord artery of fetal distress infants was(149.7?43.2)?g/L,which was significantly higher than that of normal full-term infants(t=2.941 6 P