Changes of MMP-9 expression in rabbit retina after laser irradiation at different thresholds / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 1242-1244, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-641159
ABSTRACT
AIM:
To observe the changes of MMP-9 expression in rabbit retina after laser irradiation at different thresholds of 577nm.METHODS:
Twenty-six pigmentation rabbits were randomly divided into normal control group(n=2), conventional photocoagulation group (n=6) and subliminal micropulse laser photocoagulation group (n=18).The conventional photocoagulation group was treated with 577nm laser photocoagulation, subcutaneous micro-pulsed laser photocoagulation at a working loading rate of 9%, 12% and 15%, respectively.Eighteen rabbits were again divided into three subgroups according different powers of subthreshold working loading rate of 9%(n=6), 12%(n=6) and 15%(n=6) that undertook, respectively.The expression of MMP-9 on the retina of rabbit eyes was detected by immunohistochemistry.RESULTS:
In the conventional photocoagulation group, the expression of MMP-9 in the RPE layer and the visual cell layer was strongly positive, which was significantly higher than that in the sub-micro pulse group(P0.05).CONCLUSION:
The 577nm subliminal micro-pulsed photocoagulation has high selectivity to retinal pigment epithelium at working load rate of 9%, 12% and 15%, and no damage to retinal nerve fiber layer, which is safer than conventional 577nm laser photocoagulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
International Eye Science
Ano de publicação:
2017
Tipo de documento:
Artigo
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