Update on mutations of precursor mRNA splicing factor genes linked to retinitis pigmentosa / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
; (12): 752-755, 2017.
Article
em Zh
| WPRIM
| ID: wpr-641178
Biblioteca responsável:
WPRO
ABSTRACT
Retinitis pigmentosa (RP),one of the common forms of hereditary retinal dystrophies (HRD),is typified by significant genetic heterogeneities.Executed by the spliceosome,precursor mRNA (pre-mRNA) splicing is a highly regulated process by which introns are removed and exons are ligated together.To date,more than 80 genes have been involved in RP etiology.Specially,8 of these genes (PRPF3,PRPF8,PRPF31,PRPF6,PRPF4,SNRNP200,RP9 and DHX38) encode proteins essential for pre-mRNA splicing and are expressed ubiquitously.However,mutations of these RP causative pre-mRNA splicing genes exclusively result in only retinal phenotypes,and the mechanism remains unknown.In this review,we recapitulate splicing process,summarize the mutations identified in pre-mRNA splicing genes related to RP and discuss conceivable hypothesis explaining for the consequent retinaspecific phenotypes.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Experimental Ophthalmology
Ano de publicação:
2017
Tipo de documento:
Article