Current researches of function and mechanism of peroxisome proliferator-activated receptor-γ in diabetic retinopathy / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
;
(12): 651-654, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-641245
ABSTRACT
Peroxisome proliferator-activated receptor gamma (PPAR-γ),a member of the nuclear receptor superfamily,plays a great role in delaying or even preventing the occurrence and/or development of diabetic retinopathy (DR),a complicated out-of-control waterfall-like pathophysiological processes.DR is characterized by pathways,such as inflammatory reactions,the generation of advanced glycation end products,oxidative stress,protein kinase C and so on.As one of the most important metabolic homeostasis and adipocyte differentiation regulator,the single nucleotide polymorphism and molecular structure of PPAR-γ have been proven to impact on anti-inflammation,anti-neovascularization and fibration,antioxidation,insulin sensitizer and anti-apoptosis in DR.This review provided a summary of the function and mechanism researches on PPAR-γand offered new ideas of prevention and therapy in DR.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Experimental Ophthalmology
Ano de publicação:
2017
Tipo de documento:
Artigo
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